Chlorosulfonic acid → HCID 135552973, compound

HRID 496005Notes

Reaction equation

HRID 496005 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:29])[N:18]=[C:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[N:12]2[N:11]=1)[CH3:2].[S:30]([Cl:34])(=O)(=[O:32])[OH:31].S(Cl)(Cl)(=O)=O>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:30]([Cl:34])(=[O:32])=[O:31])=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:29])[N:18]=[C:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[N:12]2[N:11]=1)[CH3:2]

Participants

4

Reactant 3

HCID 24638Chlorosulfonic acidHCID 24648Sulfuryl chlorideHCID 135604922HCID 135604922, compound

Product 1

HCID 135552973HCID 135552973, compound

Procedure

The preparation is carried out analogously to the procedure of Example 27A using 400 mg (1 mmol) of 2-(2-ethoxyphenyl)-5-methyl-7-n-nonyl-3H-imidazo-[5,1-f][1,2,4]triazin-4-one (Example 24A) and 1.18 g (10 mmol) of chlorosulphuric acid. This gives 402 mg (80.1%) of sulphonyl chloride which is directly reacted further.

Sources & evidence

ORD record
ord-2e62f3a0c3804ddebff0bf05bd1324fc
Source dataset
uspto-grants-2005_09
Patent number
US06943163B2

Reaction notes

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