Acetonitrile → HCID 11071460, compound

Participants

Reaction Steps

The title compound was prepared in 91% yield via the procedure outlined for Example 14 using 4-[2-({4-chloro-6-[[3-(4-chlorophenyl)propyl](methyl)amino]-1,3,5-triazin-2-yl}amino)ethyl]phenol and 1-(2-hydoxyethyl)piperazine to give a white solid: 1H NMR (CDCl3, 400 MHz) δ 7.23 (d, 2H, J=8.0), 7.10 (d, 2H, J=8.0), 7.09 (d, 2H, J=8.0), 6.67 (d, 2H, J=8.0), 4.88(s, br, 1H), 3.80-3.55 (m, 9H), 3.05 (s, br, 3H), 2.77 (t, 2H, J=6.6), 2.57-2.48 (m, 8H), 1.86 (s,br, 2H); low-resolution MS (ES+) m/e 526 (MH+); RP-HPLC (Capcell Pak C-18 25 cm×4.6 mm; 0-95% CH3CN in H2O with 0.1% TFA buffer; 30 minutes; 1 mL/min) tr=11.20 min, 99% purity.

Provenance & Evidence