Nitrogen → HCID 10007429, compound

Participants

Reaction Steps

To a solution of 1-{4-[2-(3,4-dimethoxy-phenoxy)ethyl]-piperazin-1-yl}-6,6-bis-(4-fluoro-phenyl)-hexan-1-one (0.7 g, 1.2 mmol) in THF (15 ml), was added LiAlH4 (100 mg, 2.4 mmol). The mixture was stirred at room temperature overnight (under N2). EtOAc was added and then washed with wate (2×10 ml), saturated NaCl (3×5 ml), dried over MgSO4, and evaporated under reduced pressure. The residue was purified by column chromatography on silica (CH2Cl2:MeOH 10:1) to give the desired product in 73% yield.

Provenance & Evidence