HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphosgene → 1-(4-Isocyanatophenyl)piperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | 1-(4-Aminophenyl)piperidin-2-one | HCID 11458178 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Isocyanatophenyl)piperidin-2-one | HCID 11195282 | — |
Reaction Steps
1.2 0.032 ml of trichloromethyl chloroformate is added under a nitrogen atmosphere to a solution of 50 mg of 1-(4-aminophenyl)piperidin-2-one (prepared from 1-(4-nitrophenyl)piperidin-2-one by hydrogenation using Raney nickel as catalyst) in 5 ml of THF, and the mixture is subsequently refluxed for 1.5 hours, giving 1-(4-isocyanatophenyl)piperidin-2-one (“AB”).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06943179B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-8cdb87b54c0b4dbcac7f853bfa815304 |
| Source note | uspto-grants-2005_09 |