反应详情

To a solution of 0.75 mol of the compound obtained in Step 1 in 200 ml of ether there are added 1.5 g of rhodium acetate and then, over 6 hours, a solution of 93 g of ethyl diazoacetate in 50 ml of ether. After stirring at ambient temperature for 16 hours, the reaction mixture is filtered and is then distilled at 50-90° C. and 0.5 torr. The residue obtained is redistilled at 80-84° C. and 0.2 torr, allowing the expected product to be isolated.

1. filtrationthe reaction mixture is filtered
2. distillationis then distilled at 50-90° C.
3. customThe residue obtained
4. distillationis redistilled at 80-84° C.
5. customto be isolated