HCID 22325119, compound → HCID 69734331, compound

Participants

Reaction Conditions

Reaction Steps

14 g of the compound obtained in Step 1 in 50 ml of ether are slowly added to a suspension of 3.1 g of AlLiH4 in 120 ml of ether. After 16 hours at reflux, the reaction mixture is cooled to 0° C., hydrolysed, filtered and then concentrated under reduced pressure. Chromatography of the residue over silica gel (dichloromethane/methanol: 90/10) allows the expected product to be isolated in a trans/cis diastereoisomeric ratio of 99/1.

Provenance & Evidence