Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | HCID 22325162 | HCID 22325162 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22325165 | HCID 22325165 | — |
Reaction Steps
8.5 g of the product obtained in Step 3 dissolved in 100 ml of tetrahydrofaran are added to 6.9 g of lithium aluminium hydride suspended in 200 ml of tetrahydrofuran. After refluxing for 16 hours, the mixture is cooled to 5° C. and hydrolysed with, in succession, 6.9 ml of water, 6.9 ml of 4N sodium hydroxide solution and then 20.7 ml of water. After customary treatment, chromatography of the residue over silica gel allows the expected product to be isolated (liquid).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06943184B2 |
|---|
| Source dataset | uspto-grants-2005_09 |
|---|
| ORD ID | ord-c66a8a7c2afa46719a620217b7d1145b |
|---|
| Source note | uspto-grants-2005_09 |
|---|
