Formic Acid → HCID 22325080, compound

Participants

Reaction Conditions

Reaction Steps

1.07 g of the compound of Example 18 diluted with 1.2 ml of water are added to a solution, cooled to 0° C., of 1.38 g of formic acid, 1.12 ml of 37% formaldehyde in water and 0.15 ml of distilled water. The reaction mixture is heated at reflux for 16 hours and is then cooled to 0° C. and 10 ml of 4N sodium hydroxide solution are added. The mixture is extracted with ether. The organic phase is treated in customary manner and evaporated. The residue is taken up in ethanol, concentrated again and then diluted with 20 ml of ether and 4 ml of 4N hydrochloric acid solution in dioxane. The mixture is stirred for 20 minutes, filtered, rinsed with ether and dried, allowing the expected product to be isolated.

Provenance & Evidence