Sodium Hydroxide → 3-(4-Methoxyphenyl)propane-1-thiol

HRID 496084Notes

Reaction equation

HRID 496084 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11]Br)=[CH:5][CH:4]=1.NC(N)=[S:15].[OH-].[Na+]>C(O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH2:11][SH:15])=[CH:5][CH:4]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 2723790ThioureaHCID 127769961-(3-Bromopropyl)-4-methoxybenzene

Product 1

HCID 131223923-(4-Methoxyphenyl)propane-1-thiol

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 3-(p-methoxyphenyl)-1-propylbromide (14 g; 61 mmol) and thiourea (5.1 g; 67 mmol) in ethanol (150 ml) was refluxed for 48 hours. Evaporation of the solvent provided a clear glassy compound, which was dissolved in 50 ml of water and treated with 100 ml of 40% aqueous sodium hydroxide.

Workup

  1. temperaturewas refluxed for 48 hours
  2. customEvaporation of the solvent
  3. customprovided a clear glassy compound, which

Sources & evidence

ORD record
ord-37efff26eca746099ce79a3aae0c6a7c
Source dataset
uspto-grants-2005_09
Patent number
US06943187B2

Reaction notes

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