反应详情

温度

25 °C

5-Acetyl-2-aminobenzenesulfonamide (see compound 13) (0.95 g, 4.4 mmol) was suspended in 96% o EtOH (50 ml) and NaBH4 (0.46 g, 12 mmol) was added in one portion. The mixture was stirred at 25° C. for 4 h and filtered through Celite and the solvent was removed under reduced pressure. The residue was treated with sat. NaHCO3 (50 ml) and extracted with EtOAc (2×50 ml), dried (Na2SO4) and evaporated to dryness. Flash-chromatography with EtOAc:n-hexane:Et3N (200:100:4, v/v/v) as eluent gave 0.35 g (37%) of 2-amino-5-(1-hydroxyethyl)benzenesulfonamide as light-brown powder. M.p. 160-162° C.

1. additionwas added in one portion
2. filtrationfiltered through Celite
3. customthe solvent was removed under reduced pressure
4. additionThe residue was treated with sat. NaHCO3 (50 ml)
5. extractionextracted with EtOAc (2×50 ml)
6. dry with materialdried (Na2SO4)
7. customevaporated to dryness