Cyclohexanecarboxaldehyde → 3-Cyclohexyl-7-cyano-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide

HRID 496104Notes

Reaction equation

HRID 496104 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH2:13])=[C:7]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:8]=1)#[N:2].[CH:14]1([CH:20]=O)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[CH:14]1([CH:20]2[NH:13][C:6]3[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][C:7]=3[S:9](=[O:10])(=[O:11])[NH:12]2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 16275CyclohexanecarboxaldehydeHCID 223239942-Amino-5-cyanobenzene-1-sulfonamide2×

Product 1

HCID 98389843-Cyclohexyl-7-cyano-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide

Procedure

5-Cyano-2-aminobenzenesulfonamide (see compound 37) was transformed by Method G (using cyclohexanecarboxaldehyde). M.p. 234-237.

Sources & evidence

ORD record
ord-f88cf6123f0f4ea091f4940ada36d7b1
Source dataset
uspto-grants-2005_09
Patent number
US06943159B1

Reaction notes

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