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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 496108Generated: October 31, 2026

Cyclohexanecarboxaldehyde → 3-Cyclohexyl-7-(2'-acetamidophenyl)-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide

https://huagongshe.com/reaction/496108

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclohexanecarboxaldehydeHCID 16275—
Reactant2-Acetamidophenylboronic acidHCID 2737789—
Reactant2-Amino-5-cyanobenzene-1-sulfonamideHCID 22323994—
Product3-Cyclohexyl-7-(2'-acetamidophenyl)-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxideHCID 22324010—

Reaction Steps

5-Iodo-2-aminobenzenesulfonamide (see compound 37) was transformed by Method H (using 2-Acetamidophenylboronic acid) and Method G (using cyclohexanecarboxaldehyde). M.p. 245-249° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06943159B1
Source datasetuspto-grants-2005_09
ORD IDord-ac6b444d8bc545f1937d0dcbc0d41212
Source noteuspto-grants-2005_09