Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 496116Generated: October 30, 2026

Cyclohexanecarboxaldehyde → 3-Cyclohexyl-7-(2'-fluorophenyl)-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide

https://huagongshe.com/reaction/496116

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclohexanecarboxaldehydeHCID 16275—
Reactant2-Fluorophenylboronic acidHCID 2734354—
Reactant2-Amino-5-cyanobenzene-1-sulfonamideHCID 22323994—
Product3-Cyclohexyl-7-(2'-fluorophenyl)-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxideHCID 22323990—

Reaction Steps

5-Iodo-2-aminobenzenesulfonamide (see compound 37) was transformed by Method H (using 2-fluorophenylboronic acid) and Method G (using cyclohexanecarboxaldehyde). M.p. 249-250° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06943159B1
Source datasetuspto-grants-2005_09
ORD IDord-43079e81bc1640e6b33054a5f2ba449d
Source noteuspto-grants-2005_09