Cyclohexanecarboxaldehyde → 3-Cyclohexyl-7-sulfamoyl-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide

HRID 496130Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](=[O:11])(=[O:10])[NH2:9])=[CH:4][C:3]=1[S:12]([NH2:15])(=[O:14])=[O:13].[CH:16]1([CH:22]=O)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([CH:22]2[NH:1][C:2]3[CH:7]=[CH:6][C:5]([S:8](=[O:10])(=[O:11])[NH2:9])=[CH:4][C:3]=3[S:12](=[O:14])(=[O:13])[NH:15]2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

Reactant 2

HCID 16275Cyclohexanecarboxaldehyde

HCID 130719484-Aminobenzene-1,3-disulfonamide2×

Product 1

HCID 223240933-Cyclohexyl-7-sulfamoyl-1,2,3,4-tetrahydro-1,2,4-benzothiadiazine-1,1-dioxide

Procedure

2-Amino-5-sulfamoylbenzenesulfonamide (see compound 101) was transformed by Method G (using cyclohexanecarboxaldehyde). M.p. 252-254° C.

Sources & evidence

ORD record: ord-1c61cf44468b496094eac5ac52fae806
Source dataset: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06943159B1

Reaction notes

Loading…