Acetic Acid → 2-Methyl-4(3H)-quinazolinone

HRID 496133Notes

Reaction equation

HRID 496133 reaction equation
[C:1]([NH2:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[C:11](O)(=O)[CH3:12]>>[CH3:11][C:12]1[NH:10][C:1](=[O:9])[C:2]2[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:4]=1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 6942Anthranilamide

Product 1

HCID 1354004572-Methyl-4(3H)-quinazolinone

Procedure

A solution of anthranilamide (13.6 g; 100 mmol) in acetic acid (100 ml) was refluxed for 60 h. The reaction mixture was evaporated to dryness, suspended in H2O, filtered and washed thoroughly with NaHCO3 until the filtrate had a pH of 8-8.5.

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. filtrationfiltered
  3. washwashed thoroughly with NaHCO3 until the filtrate

Sources & evidence

ORD record
ord-9e8b57c479c74a6d8f9f820b793e6c80
Source dataset
uspto-grants-2005_09
Patent number
US06943159B1

Reaction notes

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