Acetic Anhydride → N-(3-Methylphenyl)acetamide

HRID 496155Notes

Reaction equation

HRID 496155 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[CH:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[CH:3]=1)(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 7934m-Toluidine

Product 1

HCID 10843N-(3-Methylphenyl)acetamideYield 94%

Procedure

m-Toluidine (10 ml; 93 mmol) was added to a stirred solution of acetic anhydride (30 ml). The reaction mixture was stirred for 1,5 h at rt., evaporated to dryness, stirred with H2O and filtered to give 13 g product (94%).

Workup

  1. custom, evaporated to dryness
  2. stirringstirred with H2O
  3. filtrationfiltered

Sources & evidence

ORD record
ord-00f50790095d439a8560d4e6d24d6649
Source dataset
uspto-grants-2005_09
Patent number
US06943159B1

Reaction notes

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