Potassium Hydroxide → 6-[4-(4-(5-Bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane

HRID 4962Notes

Reaction equation

HRID 4962 reaction equation
C1(S([N:10]2[C:18]3[C:13](=[CH:14][C:15]([Br:19])=[CH:16][CH:17]=3)[C:12]([CH2:20][CH2:21][CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][N:27]([C:30]4[CH:39]=[CH:38][C:33]5[O:34][CH2:35][CH2:36][O:37][C:32]=5[CH:31]=4)[CH2:26][CH2:25]3)=[CH:11]2)(=O)=O)C=CC=CC=1.[OH-].[K+]>C(O)C>[Br:19][C:15]1[CH:14]=[C:13]2[C:18](=[CH:17][CH:16]=1)[NH:10][CH:11]=[C:12]2[CH2:20][CH2:21][CH2:22][CH2:23][N:24]1[CH2:25][CH2:26][N:27]([C:30]2[CH:39]=[CH:38][C:33]3[O:34][CH2:35][CH2:36][O:37][C:32]=3[CH:31]=2)[CH2:28][CH2:29]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 197973466-[4-(4-(1-Benzenesulfonyl-5-bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane

Product 1

HCID 197973126-[4-(4-(5-Bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.7 g of 6-[4-(4-(1-benzenesulfonyl-5-bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane is boiled for 16 hours with 1.5 g of KOH in aqueous ethanol solution, worked up in the conventional manner and gives 6-[4-(4-(5-bromoindol-3-yl)butyl)piperazino]-1,4-benzodioxane.

Sources & evidence

ORD record
ord-e8ab03e55e3649428504c580d6dadc51
Source dataset
uspto-grants-1993_09
Patent number
US05242925

Reaction notes

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