反应详情

温度

0 °C

To a solution of anhydrous MeOH (65 mL) at 0° C. was added thionyl chloride (9.03 mL, 124 mmol) slowly over a 5 min period. 2-Methyl-(L)-proline (Bachem AG, Cat. No. F-3440, Bubendorf, Switzerland) (4.0 gm, 31 mmol) was added in one portion. The reaction was stirred at 0° C. for 5 min and then warmed to rt. The reaction was then heated to 70° C. overnight. The reaction was cooled and the solvent removed to yield 2-methyl-(L)-proline, methyl ester hydrochloride as a white solid (5.72 gm).

1. additionF-3440, Bubendorf, Switzerland) (4.0 gm, 31 mmol) was added in one portion
2. temperaturewarmed to rt
3. temperatureThe reaction was then heated to 70° C. overnight
4. temperatureThe reaction was cooled
5. customthe solvent removed