化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → methyl (2S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | L-Proline, 4-hydroxy-, cis- | HCID 69248 | — |
| 生成物 | methyl (2S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride | HCID 12764091 | 97% |
反応手順
To a solution of 33.0 g (0.25 mol) of 4-hydroxy-(L)-proline and 200 mL of MeOH was added 20 mL (0.27 mol) of thionyl chloride. The reaction was warmed to reflux for 16 h and then cooled to rt and concentrated in vacuo. Trituration with Et2O afforded 44 g (97%) of 4-hydroxy-(L)-proline, methyl ester hydrochloride as a white solid which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06943180B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-621ec1b092694250a7b7f48d6006c0d9 |
| 出典メモ | uspto-grants-2005_09 |