Acetic Anhydride → N-[4-(trifluoromethylsulfonyl)phenyl]acetamide

HRID 496257Notes

Reaction equation

HRID 496257 reaction equation
[F:1][C:2]([F:14])([F:13])[S:3]([C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1)(=[O:5])=[O:4].[CH3:15][C:16](OC(C)=O)=[O:17]>CC(O)=O>[F:14][C:2]([F:13])([F:1])[S:3]([C:6]1[CH:7]=[CH:8][C:9]([NH:12][C:16](=[O:17])[CH3:15])=[CH:10][CH:11]=1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1363154-Aminophenyl trifluoromethyl sulphone

Product 1

HCID 459394N-[4-(trifluoromethylsulfonyl)phenyl]acetamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Reflux 4-trifluoromethylsulfonyl-phenylamine (5 g) and Ac2O (2.2 mL) for 1.5 hours in HOAc (20 mL). Evaporate the solvent in vacuo, then crystallize the residue in EtOAc/EtOH to obtain N-(4-trifluoromethylsulfonyl-phenyl)-acetamide. B. N-(2-Nitro-4-trifluoromethylsulfonyl-phenyl)-acetamide

Workup

  1. customEvaporate the solvent in vacuo
  2. customcrystallize the residue in EtOAc/EtOH

Sources & evidence

ORD record
ord-56ba268d981b440c97f3e9a9e9159e23
Source dataset
uspto-grants-2005_09
Patent number
US06943199B2

Reaction notes

Loading…