Phenyl chloroformate → Phenyl [5-(trifluoromethyl)pyridin-2-yl]carbamate

Participants

Reaction Steps

Dissolve 2-amino-5-trifluoromethylpyridine (162 mg, 1.0 mmole) in pyridine (2.0 mL) under nitrogen at room temperature. Add drop wise phenyl chloroformate (0.125 mL, 1.0 mmole) to the reaction mixture at room temperature. Stir the mixture for 24 hours and new spot is noticed in TLC (30% EtOAc/hexane). Evaporate the reaction mixture under vacuo and purify the crude by flash column chromatography on a silica gel using CHCl3 to afford (5-Trifluoromethyl-pyridin-2-yl)-carbamic acid phenyl ester as a white solid. B. 1′-(5-Trifluoromethyl-pyridin-2-yl-carbamoyl)spiroisobenzofuran-1,4′-piperidine

Provenance & Evidence