Ethyl Acetate → Ethanol ethylacetate

Participants

Reaction Steps

The amine compound of Formula I (10 g) in ethyl acetate (35 mL) was mixed with a solution of maleic acid (2.18 g) in ethanol (10 mL) at room temperature. Crystalline seeds were added and the mixture was stirred at room temperature for 22 h. The slurry was cooled gradually to −10° C. and stirred at that temperature for 4 h. The product was filtered, washed with ethyl acetate (10 mL), and dried overnight at 64° C. under vacuum to give the desired salt as a white solid. Ratio of rotamer 1 to 2: 2.3:97.7.

Provenance & Evidence