Ethyl Acetate → Isopropanol ethyl acetate

Participants

Reaction Conditions

Reaction Steps

The amine compound of Formula I (10 g) in ethyl acetate (40 mL) was mixed with a solution of maleic acid (2.2 g) in isopropanol (20 mL) at 55° C. The cloudy mixture was seeded, cooled slowly to 40° C., and stirred at 40° C. overnight. The resulting slurry was cooled gradually to room temperature and stirred overnight. The product was filtered, washed with 2:1 ethyl acetate/isopropanol (30 mL), and dried overnight at 55° C. under vacuum to give the desired salt as a white solid. Ratio of rotamers 1 to 2: 0.9:99.1.

Provenance & Evidence