Thionyl Chloride → HCID 22325571, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of chlorosulphonic acid (27 mL) and thionyl chloride (3.6 mL) at 0° C. was added portionwise 1-(2-propoxyphenyl)ethanone (5.0 g, 28.1 mmol). The resulting mixture was stirred at 0° C. for 20 min. and at room temperature overnight, poured cautiously into ice-water and extracted with methylene chloride. The organic solution was washed sequentially with water, aqueous sodium bicarbonate and brine, dried (MgSO4), and the solvent removed under reduced pressure to yield the title compound (6.3 g, 81%) as an off-white solid.

Provenance & Evidence