HCID 22325568, compound → HCID 22325561, compound

HRID 496314Notes

Reaction equation

HRID 496314 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[CH:9]=[C:10]([C:12]3[CH:17]=[C:16]([S:18]([N:21]4[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]4)(=[O:20])=[O:19])[CH:15]=[CH:14][C:13]=3[O:28][CH2:29][CH2:30][CH3:31])[NH:11][C:5]=2[N:4]([CH2:32][CH2:33][CH3:34])[C:3]1=[O:35]>ClCCl>[CH3:1][N:2]([CH2:7][C:9]1[C:6]2[C:7](=[O:8])[N:2]([CH3:1])[C:3](=[O:35])[N:4]([CH2:32][CH2:33][CH3:34])[C:5]=2[NH:11][C:10]=1[C:12]1[CH:17]=[C:16]([S:18]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)(=[O:20])=[O:19])[CH:15]=[CH:14][C:13]=1[O:28][CH2:29][CH2:30][CH3:31])[CH3:3]

Participants

3

Reactant 1

HCID 22325568HCID 22325568, compound

Product 1

HCID 22325561HCID 22325561, compoundYield 190.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of the title compound of Example 89 (30 mg, 0.06 mmol) and N,N-dimethylmethyleneiminium iodide (57 mg, 0.23 mmol) in anhydrous dichloromethane was stirred at room temperature overnight. The reaction mixture was purified by solid phase extraction using a Varian Bond Elut SCX cartridge (methanol for washing, methanol-ammonia for elution) to yield the title compound (32 mg, 95%).

Workup

  1. customThe reaction mixture was purified by solid phase extraction
  2. washa Varian Bond Elut SCX cartridge (methanol for washing, methanol-ammonia for elution)

Sources & evidence

ORD record
ord-7a00affc269b41649a16ded42a6de199
Source dataset
uspto-grants-2005_09
Patent number
US06943253B2

Reaction notes

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