Morpholine → HCID 17793495, compound

HRID 496374Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:4](=[O:23])[C:5]([CH3:22])=[C:6]([CH2:12][C:13]2[CH:14]=C(C=CC=2)C(O)=O)[C:7](=[O:11])[C:8]=1[O:9][CH3:10].[NH:24]1CC[O:27][CH2:26][CH2:25]1>>[CH3:1][O:2][C:3]1[C:4](=[O:23])[C:5]([CH3:22])=[C:6]([CH2:12][CH:13]2[CH2:14][O:27][CH2:26][CH2:25][NH:24]2)[C:7](=[O:11])[C:8]=1[O:9][CH3:10]

Participants

Reactant 2

HCID 8083Morpholine

HCID 9796974HCID 9796974, compound

Product 1

HCID 17793495HCID 17793495, compoundYield 55.6%

Procedure

3-(5,6-dimethoxy-3-methyl-1,4-benzoquinon-2-ylmethyl)benzoic acid (85 mg, 0.27 mmol) obtained in Example 41 and morpholine (0.036 ml, 0.41 mmol) were used, and a method similar to that described in Example 42 was employed to obtain the title compound (57 mg, 0.15 mmol, yield 54%).

Sources & evidence

ORD record: ord-5b91a3d76eb24a179acb026c02911ef0
Source dataset: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06943196B1

Reaction notes

Loading…