Morpholine → N-[3-[4-(3,5,6-trimethyl-1,4-benzoquinon-2-ylmethyl)phenyl]propionyl]morpholine

HRID 496378Notes

Reaction equation

HRID 496378 reaction equation
[CH3:1][C:2]1[C:7](=[O:8])[C:6]([CH3:9])=[C:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][C:21](O)=[O:22])=[CH:15][CH:14]=1.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[CH3:1][C:2]1[C:7](=[O:8])[C:6]([CH3:9])=[C:5]([CH3:10])[C:4](=[O:11])[C:3]=1[CH2:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][C:21]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[O:22])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 106150173-[4-(3,5,6-Trimethyl-1,4-benzoquinon-2-ylmethyl)phenyl]propionic acid

Product 1

HCID 9864725N-[3-[4-(3,5,6-trimethyl-1,4-benzoquinon-2-ylmethyl)phenyl]propionyl]morpholineYield 69%

Procedure

3-[4-(3,5,6-trimethyl-1,4-benzoquinon-2-ylmethyl)phenyl]propionic acid (25 mg, 0.08 mmol) and morpholine (0.010 ml, 0.12 mmol) were used, and a method similar to that described in Example 46 was employed to obtain the title compound (21 mg, 0.055 mmol, yield 69%).

Sources & evidence

ORD record
ord-cc356b9f44794f358772d6407e8c1d74
Source dataset
uspto-grants-2005_09
Patent number
US06943196B1

Reaction notes

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