Hydrochloric Acid → HCID 60029921, compound

Participants

Reaction Steps

To a solution of ((S)-1-{[2-((S)-2-Imidazol-1-yl-1-phenyl-ethoxy)-5-oxo-5,6,7,8-tetrahydro-naphthalen-1-ylmethyl]-carbamoyl}-3-methylsulfanyl-propyl)-carbamic acid tert-butyl ester (153 mg, 0.258 mmol) in MeOH (1 mL) was added 4 M HCl in dioxane (3 mL). The mixture was concentrated after 3 h. The residue was neutralized with aqueous NaHCO3 and the mixture was extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated to give a pale yellow oil. Purification by chromatography (5% MeOH/CH2Cl2 with 1% NH4OH) afforded the title compound as a white foam (76 mg, 0.154 mmol, 60%).

Provenance & Evidence