Triphenylphosphine → HCID 60029876, compound

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Reaction Steps

Using method in Example 154, this compound was prepared from methyl 4-(2-hydroxy-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methylsulfanylbenzoate (1.81 g, 5.3 mmol), (R)-2-imidazol-1-yl-1-phenylethanol (1.00 g, 5.3 mmol), Ph3P (2.10 g, 8.0 mmol), and diethyl azodicarboxylate (1.39 g, 8.0 mmol) and purified by a silica-column (eluting with dichloromethane-MeOH 20:1) as a solid-foam, 2.70 g, 99% yield; mp 75° C. NMR spectrum was consistent with structure. Calcd. For C30H28N2O4S.H2O:

Provenance & Evidence