Hydrochloric Acid → HCID 20828716, compound

Participants

Reaction Steps

A mixture of methyl 2-{[(2-{[(1S)-2-(1H-imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfonyl}benzoate (2.47 g, 4.54 mmol), 2N lithium hydroxide (9.1 ml), p-dioxane (45 ml) and water (27 ml) was stirred at room temperature for 2 h. Water (200 ml) was added and acidified with conc HCl to pH 3 at 0° C. Aqueous NaCl (50 ml) was added and further stirred at 0° C. for 1H. The precipitate was filtered, washed with water, and dried, to give a beige solid, 1.88 g, 78% yield; mp 230° C. (from dichloromethane-MeOH). NMR spectrum was consistent with structure. Calcd. For C29H26N2O6S.H2O:

Provenance & Evidence