Ethanolamine → HCID 60029914, compound

Participants

Reaction Steps

Using the method for Example 164, this compound was prepared from 2-{[(2-{[(1S)-2-(1H-imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfonyl}benzoic acid (159 mg, 0.30 mmol) and 2-aminoethanol (92 mg, 1.50 mmol). The reaction product was extracted into ethyl acetate and purified by a silica column (eluted with dichloromethane-MeOH 20:1) to give a pale yellow solid, 100 mg, 58% yield; mp 241-243° C. (from ethyl acetate-MeOH). NMR was consistent with the structure. Calcd. For C31H31N306S

Provenance & Evidence