Triethylamine → Ethyl 2-[(2-{[(2-{[(1S)-2-(1H-Imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfanyl}benzoyl)amino]propanoate

Participants

Reaction Steps

Using the method in Example 172, 2-{[(2-{[(1S)-2-(1H-imidazol-1-yl)-1-phenylethyl]oxy}-5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methyl]sulfanyl}benzoic acid (50 mg, 0.10 mmol, 0.20M in DMF), β-alanine ethyl ester hydrochloride (77 mg, 0.5 mmol, 1.0M in DMF) and triethylamine (51 mg, 0.5 mmol, 1.0M in DMF) were combined to give 42 mg of the desired compound: Low resolution mass spectrum (LC-MS, APCI) m/z 598 [M+H]+.

Provenance & Evidence