1-(4-Nitrophenyl)pyrrolid-3-yl methanesulphonate → 1'-(4-Nitrophenyl)[1,3]bipyrrolidinyl

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Reaction Steps

5 g (0.0174 mole) of methanesulfonic acid 1-(4-nitro-phenyl)-pyrrolidin-3yl ester (2) were heated 2 hours at 85° C. in 30 ml of pyrrolidine. The mixture was then poured on ice water until crystallization occurred. After filtrating and drying, the obtained yellow powder was chromatographed with an eluent consisting of dichloromethane/methanol (98/2). 2.6 g of derivative (1) was thus obtained (yield 53%).

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