HCID 178418840, compound → HCID 178421621, compound

HRID 496533Notes

Reaction equation

HRID 496533 reaction equation
[CH3:1][N:2]([C@@H:4]1[C:24]([OH:25])=[C:23]([C:26]([NH2:28])=[O:27])[C:21](=[O:22])[C@:20]2([OH:29])[C@H:5]1[C@@H:6]([OH:33])[C@H:7]1[C:18](=[C:19]2[OH:30])[C:16](=[O:17])[C:15]2[C:14]([OH:31])=[CH:13][CH:12]=[C:11]([Cl:32])[C:10]=2[C:8]1=[CH2:9])[CH3:3].C1C(S(O)(=O)=O)=CC(C(O)=O)=C(O)C=1.C[C@]1(O)[C@@H]2C(=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3C2)C(=O)C2C(O)=CC=CC1=2>O>[CH3:1][N:2]([C@@H:4]1[C:24]([OH:25])=[C:23]([C:26]([NH2:28])=[O:27])[C:21](=[O:22])[C@:20]2([OH:29])[C@H:5]1[C@@H:6]([OH:33])[C@H:7]1[C:18](=[C:19]2[OH:30])[C:16](=[O:17])[C:15]2[C:14]([OH:31])=[CH:13][CH:12]=[C:11]([Cl:32])[C:10]=2[C:8]1=[CH2:9])[CH3:3]

Participants

4

Reactant 2

HCID 178418840HCID 178418840, compoundHCID 178421622HCID 178421622, compound

Product 1

HCID 178421621HCID 178421621, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A rapidly disintegrating tablet containing meclocycline sulfosalicylate is added to water. The tablet disintegrates and a second tablet containing a buffer is added to the solution to raise the pH so that the tetracycline rapidly dissolves.

Workup

  1. additionThe tablet disintegrates and a second tablet containing
  2. additiona buffer is added to the solution
  3. dissolutionrapidly dissolves

Sources & evidence

ORD record
ord-6f9e5b6cf63e46c1a528c3d52ce4d0fe
Source dataset
uspto-grants-2005_09
Patent number
US06946118B1

Reaction notes

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