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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 496538Generated: October 31, 2026

Dimethylformamide → N9-cyclohexylethyl-8-diethylphosphonomethoxy-methyladenine

https://huagongshe.com/reaction/496538

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantN9-cyclohexylethyl-8-bromomethyladenineHCID 54368200—
ReactantDiethyl hydroxymethylphosphonate sodium saltHCID 86585098—
ProductN9-cyclohexylethyl-8-diethylphosphonomethoxy-methyladenineHCID 86585097—

Reaction Steps

A solution of N9-cyclohexylethyl-8-bromomethyladenine (1 mmol) in DMF was treated with a solution of diethyl hydroxymethylphosphonate sodium salt (1 mmol) in DMF at 25° C. for 1 h. Extraction and chromatography gave N9-cyclohexylethyl-8-diethylphosphonomethoxy-methyladenine as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06946115B2
Source datasetuspto-grants-2005_09
ORD IDord-bf2fa50bc9c14fa496ac615be2919c06
Source noteuspto-grants-2005_09