HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 496605Generated: October 27, 2026
Hydrochloric Acid → 1-[2-(4-Pyridinyl)ethyl]piperazine hydrochloride
https://huagongshe.com/reaction/496605
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine | HCID 22321631 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[2-(4-Pyridinyl)ethyl]piperazine hydrochloride | HCID 22321764 | 92% |
Reaction Steps
1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine (25 g, 85.8 mmol) was dissolved in methanol (100 mL) and was cooled to 0° C. Saturated HCl in methanol (100 mL) was added, and the mixture allowed to warm to room temperature for 1 h. The mixture was concentrated under vacuum and provided 1-[2-(4-pyridinyl)ethyl]piperazine hydrochloride (23.8 g, 92%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06946467B2 |
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| Source dataset | uspto-grants-2005_09 |
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| ORD ID | ord-9c493352f063490796c1719b4e4490e3 |
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| Source note | uspto-grants-2005_09 |
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