HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[2-(4-Pyridinyl)ethyl]piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine | HCID 22321631 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-[2-(4-Pyridinyl)ethyl]piperazine hydrochloride | HCID 22321764 | 87% |
Reaction Steps
Alternatively, 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine (1.0 g, 3.43 mmol) was dissolved in ethyl ether. Ethyl acetate (15 mL) saturated with HCl was added, and the mixture stirred for 30 min at room temperature. The mixture was concentrated under vacuum and provided 1-[2-(4-pyridinyl)ethyl]piperazine hydrochloride (900 mg, 87%) as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06946467B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-a53e10603e1649179442787b156f33c3 |
| Source note | uspto-grants-2005_09 |