Sodium Hydroxide → HCID 57320946, compound

Participants

Reaction Steps

A solution of methyl (2S)-2-(2-benzyl-5-nitro-benzoylamino)-4-methylsulfanyl-butyrate compound 34(d) (25.24 g, 62.78 mmol) in methanol (500 mL) was treated with 2N aqueous sodium hydroxide solution (35 mL, 70 mmol). The resulting solution was then evaporated to dryness and the solids partitioned between ethyl ether (200 mL) and water (500 mL). The aqueous material was then acidified to pH2 with 2N HCl and extracted with ethyl acetate (2×250 mL). The combined organics were washed with water(2×100 mL), brine(100 mL), filtered through phase separating paper and evaporated to give (2S)-2-(2-benzyl-5-nitro-benzoylamino)-4-methylsulfanyl-butyric acid (compound 36(a)) as a white solid, 23.57 g(96.8%).

Provenance & Evidence