反应详情

2N Aqueous sodium hydroxide solution (2.0 mL, 4 mmol) was added to a solution of compound (28) (2.06 mmol) in methanol (10 mL) at ambient temperature. After 2 hrs the reaction mixture was evaporated to remove the methanol and then partitioned between ethyl ether (20 mL) and 2N aqueous sodium hydroxide solution (20 mL). The aqueous phase was acidified to pH⅔ with 2N HCl and extracted with ethyl acetate(3×20 mL). The combined organics were washed with water (20 mL) and brine (20 mL), filtered through phase separating paper and evaporated to yield 2-benzyl-4nitrobenzoic acid (compound 29).

1. customAfter 2 hrs the reaction mixture was evaporated
2. customto remove the methanol
3. custompartitioned between ethyl ether (20 mL) and 2N aqueous sodium hydroxide solution (20 mL)
4. extractionextracted with ethyl acetate(3×20 mL)
5. washThe combined organics were washed with water (20 mL) and brine (20 mL)
6. filtrationfiltered through phase
7. customseparating paper
8. customevaporated