HCID 57010990, compound → HCID 57313599, compound

Participants

Reaction Steps

A mixture of compound 55 (2 g), stannous chloride dihydrate(4.4 g) and ethyl acetate (150 ml) was stirred and heated at reflux for 2 hours. It was then cooled and treated dropwise with aequeous ammonia(0.880) to pH 9. The white precipitate formed was filtered and washed with more ethyl acetate (150 ml). The filtrate and washings were combined, dried and evaporated to dryness to give an oil which was purified by flash chromatography on silica using ethyl acetate/iso-hexane as eluant to give methyl (2S)-2-{2-[2-(4-fluorophenyl)ethynyl]-4-aminobenzoylamino}-4-methylsulfanylbutyrate as a yellow solid (compound 56) (1.1 g).

Provenance & Evidence