HCID 22321883, compound → HCID 22321920, compound

Participants

Reaction Steps

A mixture of compound 74 (29 g), 10% Pd/C (3 g), and ethyl acetate (400 ml) was stirred under an hydrogen atmosphere for 6 hours. The catalyst was removed by filtration and replaced by fresh catalyst (3 g). The hydrogenation was then continued for another 16 hours, the catalyst was again filtered off, the filtrate evaporated to dryness and the residue treated with iso-hexane to give a white precipitate which was isolated by filtration and dried to give compound 75 (23.5 g).

Provenance & Evidence