2-(Methylamino)ethanol → 2-[(2-Fluoro-benzyl)-methyl-amino]-ethanol

Participants

Reaction Conditions

Reaction Steps

A mix of 2-Fluorobenzyl methanesulfonate (Step A, 5 g, 24.5 mmol) and 2-(Methylamino)-ethanol (18.4 g, 244.9 mmol) was heated under argon at 120° C. with stirring for 7 hours. The mixture was cooled to room temperature and concentrated. The crude residue was purified by flash chromatography on silica gel column (chloroform:methanol, 90:10 spiked with triethylamine) to provide the title compound.

Provenance & Evidence