N,N'-bis-(2-amino-ethyl)-N,N'-dimethyl-propane-1,3-diamine → 6-{2-[methyl-(3-{methyl-[2-(7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-amino}-propyl)-amino]-ethylamino}-5,10-diaza-benzo[c]fluoren-7-one

HRID 496743Notes

Reaction equation

HRID 496743 reaction equation
[O:1]=[C:2]1[C:14]2[C:13](OS(C3C=CC(C)=CC=3)(=O)=O)=[N:12][C:11]3[CH:26]=[CH:27][CH:28]=[CH:29][C:10]=3[C:9]=2[C:8]2[CH:7]=[N:6][CH:5]=[CH:4][C:3]1=2.[NH2:30][CH2:31][CH2:32][N:33]([CH3:42])[CH2:34][CH2:35][CH2:36][N:37]([CH2:39][CH2:40][NH2:41])[CH3:38]>>[CH3:38][N:37]([CH2:36][CH2:35][CH2:34][N:33]([CH3:42])[CH2:32][CH2:31][NH:30][C:13]1[C:14]2[C:2](=[O:1])[C:3]3[CH:4]=[CH:5][N:6]=[CH:7][C:8]=3[C:9]=2[C:10]2[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=2[N:12]=1)[CH2:39][CH2:40][NH:41][C:13]1[C:14]2[C:2](=[O:1])[C:3]3[CH:4]=[CH:5][N:6]=[CH:7][C:8]=3[C:9]=2[C:10]2[CH:29]=[CH:28][CH:27]=[CH:26][C:11]=2[N:12]=1

Participants

3

Reactant 2

HCID 10607670N,N'-bis-(2-amino-ethyl)-N,N'-dimethyl-propane-1,3-diamineHCID 22322083toluene-4-sulfonic acid 7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-yl ester

Product 1

HCID 100779846-{2-[methyl-(3-{methyl-[2-(7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-amino}-propyl)-amino]-ethylamino}-5,10-diaza-benzo[c]fluoren-7-one

Procedure

In a similar manner to Example 4, this compound was obtained starting from toluene-4-sulfonic acid 7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-yl ester (the compound of Reference Example 6c-1) and N,N′-bis-(2-amino-ethyl)-N,N′-dimethyl-propane-1,3-diamine. The desired product was obtained as a reddish powder.

Workup

  1. customIn a similar manner to Example 4, this compound was obtained

Sources & evidence

ORD record
ord-3dae7e5cbe56416085d8c80447e210ea
Source dataset
uspto-grants-2005_09
Patent number
US06946472B2

Reaction notes

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