N,N'-bis-(2-amino-ethyl)-N,N'-dimethyl-propane-1,3-diamine → 3-methoxy-6-{2-[(3-{[2-(3-methoxy-4-methyl-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-methyl-amino}-propyl)-methyl-amino]-ethylamino}-4-methyl-5,10-diaza-benzo[c]fluoren-7-one
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:18]3[C:17]4[CH:16]=[N:15][CH:14]=[CH:13][C:12]=4[C:11](=[O:19])[C:10]=3[C:9](OS(C3C=CC(C)=CC=3)(=O)=O)=[N:8][C:7]=2[C:31]=1[CH3:32].[NH2:33][CH2:34][CH2:35][N:36]([CH3:45])[CH2:37][CH2:38][CH2:39][N:40]([CH2:42][CH2:43][NH2:44])[CH3:41]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:18]3[C:17]4[CH:16]=[N:15][CH:14]=[CH:13][C:12]=4[C:11](=[O:19])[C:10]=3[C:9]([NH:44][CH2:43][CH2:42][N:40]([CH2:39][CH2:38][CH2:37][N:36]([CH2:35][CH2:34][NH:33][C:9]3[C:10]4[C:11](=[O:19])[C:12]5[CH:13]=[CH:14][N:15]=[CH:16][C:17]=5[C:18]=4[C:6]4[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[C:31]([CH3:32])[C:7]=4[N:8]=3)[CH3:45])[CH3:41])=[N:8][C:7]=2[C:31]=1[CH3:32]Participants
3
Reactant 2
Product 1
Procedure
In a similar manner to Example 4, 3-methoxy-6-{2-[(3-{[2-(3-methoxy-4-methyl-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-methyl-amino}-propyl)-methyl-amino]-ethylamino}-4-methyl-5,10-diaza-benzo[c]fluoren-7-one was obtained starting from toluene-4-sulfonic acid 3-methoxy-4-methyl-7-oxo-7H-5,10-diaza-benzo[c]fluoren-6-yl ester (the compound of Reference Example 2c-1) and N,N′-bis-(2-amino-ethyl)-N,N′-dimethyl-propane-1,3-diamine. The desired product was obtained as a reddish powder.
Sources & evidence
- ORD record
- ord-107f2bc927164f55ae83dff18cc0edc6
- Source dataset
- uspto-grants-2005_09
- Patent number
- US06946472B2
Reaction notes
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