1,4-Dioxane hydrochloride → N-Propyl-N-propoxyamine hydrochloride

HRID 496777Notes

Reaction equation

HRID 496777 reaction equation
C([N:8]([CH2:13][CH2:14][CH3:15])[O:9][CH2:10][CH2:11][CH3:12])(OC(C)(C)C)=O.[ClH:16].O1CCOCC1>>[ClH:16].[CH2:13]([NH:8][O:9][CH2:10][CH2:11][CH3:12])[CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22322626N-Boc-N-propyl-N-propoxyamine

Product 1

HCID 22322517N-Propyl-N-propoxyamine hydrochloride

Procedure

N-Boc-N-propyl-N-propoxyamine (5.8 g) was dissolved in 4N HCl/dioxane (10 mL) and stirred at room temperature for 7 hours. The solvent was removed in vacuo and the residue triturated with diethyl ether. The resulting yellow solid (2.1 g) was collected by filtration and washed with diethyl ether.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue triturated with diethyl ether
  3. filtrationThe resulting yellow solid (2.1 g) was collected by filtration
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-8dd856e5661d4b459a1e612f7c94e45d
Source dataset
uspto-grants-2005_09
Patent number
US06946481B1

Reaction notes

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