HRID496794

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID962

Water

H2O

结构：Cc1nc(-c2cccc(OC(C(=O)Nc3ccc(-c4ccccc4S(C)(=O)=O)cc3)c3ccccc3)c2)no1

HCID69735012

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O.CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C(Oc2cccc(C(=N)N)c2)c2ccccc2)cc1

HCID69735004

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of 150 mg (0.278 mmol) of N-(2′-methanesulfonylbiphenyl-4-yl)-2-[3-(5-methyl-[1,2,4]oxadiazol-3-yl)phenoxy]-2-phenylacetamide in 7 ml of methanol is treated with 100 mg of water-moist Raney nickel and 70 mg of acetic acid and hydrogenated for 18 hours at room temperature and normal pressure. The reaction mixture is filtered, the filtrate is evaporated and the residue is stirred with diethyl ether. A colourless solid is obtained; FAB 500

WORKUP

后处理

filtrationThe reaction mixture is filtered
customthe filtrate is evaporated
customA colourless solid is obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-555507f6cf9b4da4a965adc6bf849618
来源数据集: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06946489B2
来源说明: uspto-grants-2005_09

反应 SMILES

[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:39])[CH:19]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([C:33]3[N:37]=C(C)O[N:34]=3)[CH:28]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:13][CH:12]=1)(=[O:4])=[O:3].O.[C:41]([OH:44])(=[O:43])[CH3:42]>CO>[C:41]([OH:44])(=[O:43])[CH3:42].[C:33]([C:29]1[CH:28]=[C:27]([CH:32]=[CH:31][CH:30]=1)[O:26][CH:19]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:18]([NH:17][C:14]1[CH:13]=[CH:12][C:11]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:2]([CH3:1])(=[O:4])=[O:3])=[CH:16][CH:15]=1)=[O:39])(=[NH:34])[NH2:37]