Sodium Hydroxide → HCID 178437663, compound

HRID 496814Notes

Reaction equation

HRID 496814 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[C:4]([CH2:10][CH3:11])[N:3]=1.[OH-:12].[Na+]>O>[NH4+:3].[Cl:1][C:2]1[N:7]=[C:6]([OH:12])[C:5]([F:9])=[C:4]([CH2:10][CH3:11])[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 223233532,4-Dichloro-6-ethyl-5-fluoropyrimidine

Product 1

HCID 178437663HCID 178437663, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of the compound of part (ii) (40 kg) and water (10 kg) was heated to 90° C. and 4N aqueous sodium hydroxide solution (127 L) added.

Sources & evidence

ORD record
ord-e1b79d1b56584592a04b3820bdb8b0df
Source dataset
uspto-grants-2005_09
Patent number
US06946555B2

Reaction notes

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