HCID 53753365, compound → HCID 22323303, compound

Participants

Reaction Steps

A sample of 3-cyano-4-phenyl-3-buten-2-one, prepared according to the procedure of Example 9 (5.0 g, 29.24 mmol), was dissolved in methanol (100 mL) containing 10% Pd—C (ca. 0.1 g, Aldrich) and hydrogenated at 50 psi hydrogen pressure for 2 h. The mixture was filtered through Celite to remove catalyst and an analytical sample prepared by concentrating a portion of the filtrate to give a pale-yellow oil. The oil was passed through a short pad of silica gel (hexane—ethyl acetate 7:3) and the desired fractions evaporated to give the title compound as a straw-colored oil. The remaining material was used directly in the next step.

Provenance & Evidence