Toluene → 3-Buten-2-one, 1,1,1-trifluoro-4-(4-methylphenyl)-, (E)-

Participants

Role	Name	HCID	Charge
Reactant	Toluene	HCID 1140	—
Reactant	4-Ethoxy-1,1,1-trifluoro-3-buten-2-one	HCID 2780395	—
Catalyst	Zincchloride	HCID 3007855	—
Solvent	Dichloromethane	HCID 6344	—
Product	3-Buten-2-one, 1,1,1-trifluoro-4-(4-methylphenyl)-, (E)-	HCID 69590228	—

Reaction Conditions

Temperature	22 °C

Reaction Steps

To a solution of toluene (8, R1=p-CH3, R3=R4=H, 10 mmol) and 4-ethoxy-1,1,1-trifluoro-3-buten-2-one (10 mmol) in dichloromethane (10 mL) is added zinc chloride (0.015 g, 1.5 mol %). The reaction mixture is stirred for 3 h at 22° C. The resulting precipitate is filtered, washed with dichloromethane (2×15 mL) and dried.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06706927B2
Source dataset	uspto-grants-2004_03
ORD ID	ord-2405b60c3412430e9f17544b8a0711ab
Source note	uspto-grants-2004_03