HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-Chloro-2-[2-(dimethylamino)-2-oxoethoxy]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | 2-(Dimethylamino)-2-oxoethyl 4-chloro-2-(2-(dimethylamino)-2-oxoethoxy)benzoate | HCID 22322432 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Chloro-2-[2-(dimethylamino)-2-oxoethoxy]benzoic acid | HCID 11253901 | 159.6% |
Reaction Steps
The product from step (v) (1.0 g) was dissolved in a 2:1 water:methanol mixture (15 ml) and LiOH.H2O added. After 2 hours 2M aqueous HCl solution and ethyl acetate were added, the organic phase separated, dried and concentrated to give the sub-titled product as a solid (1.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06946478B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-20f5ec11ad2a4a5db859d7a8ecff6b44 |
| Source note | uspto-grants-2005_09 |